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Since 1976, when the National Institute on Alcohol Abuse and Alcoholism (NIAAA) issued its first report on alcohol misuse by college students, research advances have transformed our understanding of excessive drinking on college campuses and the negative outcomes that follow from it. For instance, we now know that a broad array of factors influence whether a particular college student will choose...

In the United States, alcohol use typically begins and escalates during adolescence and young adulthood. To describe the historical and developmental trends in substance use in this age group, the Monitoring the Future (MTF) study (Johnston et al. 2012) was designed in 1975. Since then, this ongoing national-cohort sequential longitudinal study assessing the epidemiology and etiology of substance...

Introduction

Use of alcohol and related problems cause significant global and individual health-related harms, and alcohol use is currently the third-leading cause of preventable death in the United States.^1,2 Alcohol and cannabis are among the most commonly used psychoactive substances in the United States.³ Although concurrent use of alcohol and cannabis (i.e., co-use: defined as using both...

Brain imaging technology has allowed researchers to conduct rigorous studies of the dynamic course of alcoholism through periods of drinking, sobriety, and relapse and to gain insights into the effects of chronic alcoholism on the human brain. Magnetic resonance imaging (MRI) studies have distinguished alcohol-related brain effects that are permanent from those that are reversible with abstinence...

Alcohol misuse is the fifth-leading risk factor for premature death and disability worldwide, and, adjusting for age, alcohol is the leading risk factor for mortality and the overall burden of disease in the 15 to 59 age group. According to the World Health Organization, in 2004, 4.5% of the global burden of disease and injury was attributable to alcohol: 7.4% for men and 1.4% for women.

Globally, more than 2 million new cases of breast cancer are reported annually. The United States alone has more than 496,000 new cases every year. The worldwide prevalence is approximately 6.8 million cases. Although many risk factors for breast cancer are not modifiable, understanding the role of the factors that can be altered is critical. Alcohol consumption is a modifiable factor. Studies of...

There has been a global increase in alcohol misuse and rates of alcohol use disorder (AUD) over the last two decades. Recent substantial increases in the United States come from dramatic rises in the prevalence of alcohol misuse and AUD in women relative to men (women, 84% increase; men, 35% increase).

Alcohol use disorder (AUD) commonly is associated with compromise in neurobiological and/or neurobehavioral processes. The severity of this compromise varies across individuals and outcomes, as does the degree to which recovery of function is achieved. This narrative review first summarizes neurobehavioral, neurophysiological, structural, and neurochemical aberrations/deficits that are frequently...

A Look Back

NIAAA’s 50th anniversary is truly a highlight in the history of public health. More than 5 decades ago, a group of researchers, advocates, and elected officials made a farsighted decision when they pushed for the creation of a federal institution dedicated to research that improves the lives of millions of Americans and their families devastated by alcohol misuse. As a result, on...