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Introduction

A vast body of evidence from human studies and animal research clearly indicates that chronic, heavy alcohol consumption causes structural damage and/or disrupts normal organ function in virtually every tissue of the body. In heavy consumers of alcohol, the liver is especially susceptible to alcohol-induced injury.^1,2 Additionally, several other organs—including the gastrointestinal...

The multiple genetic, environmental, and behavioral factors that play a role in the development of alcohol use disorders (AUDs) make it difficult to identify individual genes linked to these disorders. Nevertheless, some genetic risk factors (i.e., specific variants) associated with AUDs have been identified within many genes, some of which code for proteins involved in known biological pathways...

Individuals seeking to change their alcohol use form a heterogeneous group with varied treatment goals—including moderation and abstinence—that therefore requires flexible treatment options. The availability of alcohol in the United States, and the pervasive social pressure to drink, warrant treatments that support individuals outside the treatment environment and that foster coping and self...

Continuing care is widely believed to be an important component of effective treatment for substance use disorder, particularly for those individuals with greater problem severity. The purpose of this review was to examine the research literature on continuing care for alcohol and drug use disorders, including studies that addressed efficacy, moderators, mechanisms of action, and economic impact...

Alcohol has been a part of human culture for all of recorded history, with almost all societies in which alcohol is consumed experiencing net health and social problems (McGovern 2009; Tramacere et al. 2012b, c). With the industrialization of alcohol production and the globalization of its marketing and promotion, alcohol consumption and its related harms have increased worldwide (see Alcohol...

Introduction

Although the awareness of the negative impact of prenatal alcohol exposure (PAE) was already alluded to in ancient writings¹ and the impact of ethanol embryopathy in animal models was studied as early as 1910,² the conceptualization of a syndrome associated with PAE was not recognized within modern medicine until the mid-20th century.^3,4 The syndrome or disorder was not uniformly...

Brain imaging technology has allowed researchers to conduct rigorous studies of the dynamic course of alcoholism through periods of drinking, sobriety, and relapse and to gain insights into the effects of chronic alcoholism on the human brain. Magnetic resonance imaging (MRI) studies have distinguished alcohol-related brain effects that are permanent from those that are reversible with abstinence...

Introduction

Racial/ethnic minority groups comprise a large proportion of the U.S. population and evidence a substantial need for treatment of substance use disorder (SUD). Analysis of the most recent, reliable data available—the 2018 National Survey on Drug Use and Health (NSDUH)¹—found that the prevalence of past-year SUD among those age 12 and older was higher among some racial/ethnic minority...