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Alcohol’s Burden on Immunity Following Burn, Hemorrhagic Shock, or Traumatic Brain Injury

The incidence of traumatic injury in alcohol-intoxicated individuals continues to escalate. According to the Centers for Disease Control and Prevention (2012a), more than 38 million American alcohol users consume 5 or more drinks on the same occasion (i.e., binge drink) and do so about 4 times per month. This behavior is highly conducive to unintentional or accidental traumatic injury, which...

Chronic Diseases and Conditions Related to Alcohol Use

Alcohol has been a part of human culture for all of recorded history, with almost all societies in which alcohol is consumed experiencing net health and social problems (McGovern 2009; Tramacere et al. 2012b, c). With the industrialization of alcohol production and the globalization of its marketing and promotion, alcohol consumption and its related harms have increased worldwide (see Alcohol...

Epigenetic Targets for Reversing Immune Defects Caused by Alcohol Exposure

Extensive clinical and experimental data suggest that alcohol consumption has dose-dependent modulatory effects on the immune system that influence the two arms of the immune response (i.e., innate and adaptive immune responses). In many other organ systems, such as the brain and liver, alcohol consumption has been shown to alter factors that can modify gene expression without changing the DNA...

Alcohol’s Effects on the Brain: Neuroimaging Results in Humans and Animal Models

Brain imaging technology has allowed researchers to conduct rigorous studies of the dynamic course of alcoholism through periods of drinking, sobriety, and relapse and to gain insights into the effects of chronic alcoholism on the human brain. Magnetic resonance imaging (MRI) studies have distinguished alcohol-related brain effects that are permanent from those that are reversible with abstinence...

Alcohol’s Effects on the Cardiovascular System

Alcohol use has complex effects on cardiovascular (CV) health. The associations between drinking and CV diseases such as hypertension, coronary heart disease, stroke, peripheral arterial disease, and cardiomyopathy have been studied extensively and are outlined in this review. Although many behavioral, genetic, and biologic variants influence the interconnection between alcohol use and CV disease...

Effects of Alcohol on Tumor Growth, Metastasis, Immune Response, and Host Survival

Alcohol use and abuse have been implicated as etiological factors in the genesis of an increasing number of cancer types in both men and women. In 2012, the International Agency for Research on Cancer (IARC) listed both beverage alcohol (i.e., ethanol) and its major metabolite, acetaldehyde, as tumor-inducing substances (i.e., carcinogens) in humans. The most recent worldwide statistic from 2002...

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