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17 November 2022

A Look Back

NIAAA’s 50th anniversary is truly a highlight in the history of public health. More than 5 decades ago, a group of researchers, advocates, and elected officials made a farsighted decision when they pushed for the creation of a federal institution dedicated to research that improves the lives of millions of Americans and their families devastated by alcohol misuse. As a result, on...

13 September 2019

Research on associations of suicidal behavior, including suicide and suicide attempt, with alcohol use disorder (AUD) and acute use of alcohol (AUA) are discussed, with an emphasis on data from meta-analyses. Based on psychological autopsy investigations, results indicate that AUD is prevalent among individuals who die by suicide. Results also indicate that AUD is a potent risk factor for suicidal...

1 December 2012

Although stress is known to be an important contributing factor to alcohol abuse and alcoholism, the interaction between stress and alcohol drinking behavior, as well as the mechanisms underlying this interaction in the context of dependence are complex and not well understood. On the one hand, alcohol is an effective anxiety-reducing agent (i.e., anxiolytic). Hence, motivation for drinking may be...

5 November 2020

Recent epidemiological research has identified alarming trends in drinking patterns of girls and women in the United States. In recent years, the amount and frequency of alcohol use are increasing in White and Hispanic girls and young women in contrast to decreasing patterns of heavy alcohol use in boys and young men.^1,2 Similarly, current and binge alcohol use is rising among older women,^3,4 resu...

1 January 2012

A major goal of genetic research into alcoholism and related traits is to better understand the biology underlying this disease by identifying specific genes in which variations contribute to a person’s risk of developing the disease and then examining the pathways through which these genes and their variants affect the disease. Researchers hope to use this knowledge to develop new, more effective...

1 December 2012

The development of alcohol dependence is a complex process influenced by both genetic and environmental risk factors (Prescott and Kendler 1999). The relative contributions of genetic and environmental influences fluctuate across development. During adolescence the initiation of alcohol use is strongly influenced by environmental factors (Dick et al. 2007; Heath et al. 1997; Karvonen 1995...

1 January 2018

Alcohol use disorder (AUD) and post-traumatic stress disorder (PTSD) are highly comorbid, and treatment outcomes are worse in individuals with both disorders. Several neurobiological systems have been implicated in the development and maintenance of AUD and PTSD, and pharmacologic interventions targeting these systems for singular diagnoses of AUD or PTSD have proven effective. However, there are...

9 September 2021

Introduction

Adolescence is marked by significant social, emotional, cognitive, and physical changes, as individuals transition from childhood to adulthood. Although the exact definition of adolescence tends to vary, recent findings regarding adolescent development and growth include individuals between the ages of 10 and 24.¹ Consistent with this defined age range, the human brain continues to...

24 February 2022

Introduction

The establishment of the National Institute on Alcohol Abuse and Alcoholism (NIAAA) in 1971 was bracketed by three seminal papers that laid the groundwork for the field of fetal alcohol spectrum disorders (FASD) research. In 1968, Lemoine et al.¹ described children with birth defects and neurodevelopmental disorders associated with prenatal alcohol exposure (PAE). This French...

1 January 2015