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Focus On: Ethnicity and the Social and Health Harms From Drinking

Research has shown differential social and health effects from alcohol use across U.S. ethnic groups, including Whites, Blacks, Hispanics, Asians, and Native Americans. The relationship of ethnicity to alcohol-related social and health harms partially is attributed to the different rates and patterns of drinking across ethnicities. Some ethnic groups have higher rates of alcohol consumption...

Behavioral Treatments for Alcohol Use Disorder and Post-Traumatic Stress Disorder

Alcohol use disorder (AUD) and post-traumatic stress disorder (PTSD) are highly prevalent and debilitating psychiatric conditions that commonly co-occur. Individuals with comorbid AUD and PTSD incur heightened risk for other psychiatric problems (e.g., depression and anxiety), impaired vocational and social functioning, and poor treatment outcomes. This review describes evidence-supported...

Community Indicators: Assessing the Impact of Alcohol Use on Communities

In the United States and other countries around the world, researchers have long been interested in community-level measurement of population health in the form of community indicators. Community indicators are measures that communicate information about a given dimension of a community’s well-being (Besleme and Mullin 1997). In the United States, the current popularity of community indicators can...

The Gastrointestinal Microbiome: Alcohol Effects on the Composition of Intestinal Microbiota

It has been estimated that approximately 2 billion people worldwide drink alcohol on a daily basis, with more than 70 million people having a diagnosed alcohol use disorder (World Health Organization 2004). Globally, alcohol use is the fifth leading risk factor for premature death and disability among people between the ages of 15 and 49 (Lim et al. 2012). Excessive alcohol consumption in the...

Epigenetic Events in Liver Cancer Resulting From Alcoholic Liver Disease

The molecular pathogenesis of liver cancer (i.e., hepatocellular carcinoma [HCC]) is a multistep process that involves both genetic changes, such as chromosomal abnormalities and mutations of the DNA sequence (i.e., somatic mutations), and epigenetic mechanisms, such as chemical modifications of the DNA and the histone proteins around which the DNA is wrapped to form the chromosomes, microRNA...

Religious Affiliation and Spiritual Practices: An Examination of the Role of Spirituality in Alcohol Use and Alcohol Use Disorder

Drinking Over the Lifespan: Focus on College Ages

Approximately 41 percent of 18- to 24-year-olds are enrolled in a postsecondary degree-granting institution (National Center for Education Statistics 2013). As a group, college students, and particularly those at residential colleges (Presley et al. 2002), often drink heavily and experience myriad associated negative consequences. This selective review discusses the special characteristics of the...

Uniting Epidemiology and Experimental Disease Models for Alcohol-Related Pancreatic Disease

Findings from epidemiologic studies and research with experimental animal models provide insights into alcohol-related disease pathogeneses. Epidemiologic data indicate that heavy drinking and smoking are associated with high rates of pancreatic disease. Less clear is the association between lower levels of drinking and pancreatitis. Intriguingly, a very low percentage of drinkers develop clinical...

Suicidal Behavior: Links Between Alcohol Use Disorder and Acute Use of Alcohol

Research on associations of suicidal behavior, including suicide and suicide attempt, with alcohol use disorder (AUD) and acute use of alcohol (AUA) are discussed, with an emphasis on data from meta-analyses. Based on psychological autopsy investigations, results indicate that AUD is prevalent among individuals who die by suicide. Results also indicate that AUD is a potent risk factor for suicidal...

The First Line of Defense: The Effects of Alcohol on Post-Burn Intestinal Barrier, Immune Cells, and Microbiome

Each year 2.5 million people die from alcohol abuse and its related morbidities worldwide, making alcohol related deaths among the highest preventable causes of death, and the greatest cause of premature death and disability in men between ages 15 and 59 (World Health Organization 2011). Alcohol abuse predisposes individuals to life-threatening conditions such as alcoholic liver disease (ALD)...