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Noncoding RNA and Alcohol Use Disorder: A Scoping Review of Current Research and Knowledge Gaps

Key Takeaways

  • Noncoding RNAs (ncRNAs) dominate the genomes of mammals, including humans, and epigenetically transduce the effects of the environment into all cells and tissues.
  • Understanding of the role of ncRNAs in the pathogenesis of alcohol use disorder (AUD) is in its infancy.
  • Most of the research has focused on very few classes of ncRNAs, mainly on microRNAs.
  • Research has mainly focused on...

Influence of Alcohol on the Intestinal Immune System

Key Takeaways

  • Chronic alcohol consumption disrupts the intestinal barrier, causing dysbiosis, increased mucus thickness, and reduced antimicrobial peptides. This promotes bacterial translocation and systemic inflammation, which contribute to alcohol-associated liver disease (ALD).
  • Alcohol alters the intestinal immune system by disrupting the balance between immune tolerance and activation. This...

Information for Reviewers

Thank you for your interest in reviewing an article for Alcohol Research: Current Reviews (ARCR). Journal reviewers are invited to evaluate manuscripts because they are recognized subject matter experts in alcohol research. Their input is vital in ensuring that the journal publishes only the highest quality manuscripts. If you have been invited to review an article, you can learn more about the...