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Alcohol consumption is a leading risk factor for morbidity and mortality related to both intentional (i.e., violence- related) and unintentional injury. In 2000, 16.2 percent of deaths and 13.2 percent of disability-adjusted life years (DALYs) from injuries, worldwide, were estimated to be attributable to alcohol (Rehm et al. 2009). Alcohol affects psychomotor skills, including reaction time, as...

Even though the prevalence of alcohol use in the United States generally is lower among women compared with men (Substance Abuse and Mental Health Services Administration [SAMHSA] 2011), this gap has narrowed (Grucza et al. 2008). Furthermore, although women consume alcohol at lower levels than men, their body composition puts them at higher risk than men of developing some alcohol-related...

In the United States and other countries around the world, researchers have long been interested in community-level measurement of population health in the form of community indicators. Community indicators are measures that communicate information about a given dimension of a community’s well-being (Besleme and Mullin 1997). In the United States, the current popularity of community indicators can...

The burden of alcohol use usually is expressed as a function of the contribution of alcohol use in a population to morbidity and mortality in that population (Rehm et al. 2010). It is difficult to calculate the burden of alcohol use for middle-school and high-school adolescents (see Patrick and Schulembery, p. 193 in this issue) and nearly impossible to do so for children and preadolescents. There...

Since 1976, when the National Institute on Alcohol Abuse and Alcoholism (NIAAA) issued its first report on alcohol misuse by college students, research advances have transformed our understanding of excessive drinking on college campuses and the negative outcomes that follow from it. For instance, we now know that a broad array of factors influence whether a particular college student will choose...

Research is continuing to investigate how alcohol impacts chronic disease. The National Institute on Alcohol Abuse and Alcoholism (NIAAA) hosted a 2-day Expert Panel on Alcohol and Chronic Disease Epidemiology in August 2011 to review the state of the field on alcohol and chronic disease. The panel was chaired by Kenneth J. Mukamal, M.D., and Rosalind A. Breslow, Ph.D., M.P.H., R.D., and was...

Alcohol exposure of the developing embryo and fetus in utero can have a wide range of detrimental effects collectively referred to as fetal alcohol spectrum disorders (FASD). Researchers are intensively investigating the mechanisms that may contribute to alcohol’s effects on the developing organism and to the resulting consequences, particularly with respect to the cognitive and behavioral...

According to the World Health Organization (WHO) Global Burden of Disease Project, alcohol accounts for approximately 3.2 percent of all deaths per year worldwide (corresponding to 1.8 million people) and is causally related to more than 60 different medical conditions (Rehm et al. 2004). Cancer formation (i.e., carcinogenesis) is one of the most significant consequences attributed to alcohol...

The term “epigenetics” is rapidly becoming one of the more important watchwords in the field of alcohol research. Put simply, epigenetics is the study of changes in gene function that occur without a change in the body’s genetic code, instead relying on epigenetic markers on, among others, the DNA and certain nuclear proteins to turn genes “on” and “off.” Epigenetic changes also are brought about...

Children exposed to severe adversity early in life are at increased risk of subsequently developing mental health problems, including alcohol dependence. In general, the onset of trauma precedes the onset of alcohol dependence. Although it is impossible to establish a direct causal relationship, this temporal relationship suggests a robust and positive relationship between exposure to early-life...