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Biology, Genetics, and Environment: Underlying Factors Influencing Alcohol Metabolism

Epidemiological studies have demonstrated that drinking patterns and the prevalence of alcohol-related adverse consequences, including alcohol use disorder (AUD), differ substantially among racial/ethnic groups in the United States. For example, analyses comparing drinking patterns and their consequences among Whites, Blacks, Asians, and Hispanics found the following: Whites have the highest risk...

The Influence of Gender and Sexual Orientation on Alcohol Use and Alcohol-Related Problems: Toward a Global Perspective

The prevalence of alcohol use and the contrast between the drinking patterns of men and women vary widely across the globe. For instance, rates of current drinking ranged from 3 percent and 37 percent for women and men, respectively, in the Indian state of Karnataka to 94 percent and 97 percent for women and men in Denmark (Wilsnack et al. 2009). Overall, however, men have higher rates of alcohol...

Advances in Electrophysiological Research

The discovery and recording of electrical activity (electroencephalography [EEG]) in the human brain in 1924 by the German physician Hans Berger (Collura 1993; Haas 2003) has led to numerous scientific breakthroughs and clinical applications (Borck 2005; Gloor 1994). Recording brain activity in humans using scalp electrodes provides a noninvasive, sensitive measure of ongoing brain function...

Neuroimmune Function and the Consequences of Alcohol Exposure

Induction of neuroimmune genes by binge drinking increases neuronal excitability and oxidative stress, contributing to the neurobiology of alcohol dependence and causing neurodegeneration. Ethanol exposure activates signaling pathways featuring high-mobility group box 1 and Toll-like receptor 4 (TLR4), resulting in induction of the transcription factor nuclear factor kappa-light-chain-enhancer of...

Impact of Alcohol Abuse on the Adaptive Immune System

In the United States, alcohol use disorder (AUD) is the third-leading cause of preventable death. It is associated with increased susceptibility to bacterial pneumonia; viral infections, such as HIV and hepatitis C virus (HCV); and increased postoperative morbidity and mortality. This increased susceptibility is mediated in part by functional alterations in various cells of the immune system. The...

Utilization of Magnetic Resonance Imaging in Research Involving Animal Models of Fetal Alcohol Spectrum Disorders

Neuroimaging, particularly magnetic resonance imaging (MRI), has begun to tease apart the underlying mechanisms behind alcohol’s deleterious effects on the fetus and eventually may lead to earlier detection of what can be devastating child neurodevelopmental deficits. In 1968, researchers first reported an association between prenatal alcohol exposure and what can be persistent adverse cognitive...

Influence of Social Media on Alcohol Use in Adolescents and Young Adults

Participation in online social media Web sites (e.g., Facebook and Twitter) has skyrocketed in recent years and created a new environment in which adolescents and young adults may be exposed to and influenced by alcohol-related content. Thus, young people are exposed to and display pro-alcohol messages and images through online portrayals of drinking on personal pages as well as unregulated...

Prevalence and Predictors of Adolescent Alcohol Use and Binge Drinking in the United States

In the United States, alcohol use typically begins and escalates during adolescence and young adulthood. To describe the historical and developmental trends in substance use in this age group, the Monitoring the Future (MTF) study (Johnston et al. 2012) was designed in 1975. Since then, this ongoing national-cohort sequential longitudinal study assessing the epidemiology and etiology of substance...

The Burden of Alcohol Use: Focus on Children and Preadolescents

The burden of alcohol use usually is expressed as a function of the contribution of alcohol use in a population to morbidity and mortality in that population (Rehm et al. 2010). It is difficult to calculate the burden of alcohol use for middle-school and high-school adolescents (see Patrick and Schulembery, p. 193 in this issue) and nearly impossible to do so for children and preadolescents. There...

Stress and Alcohol: Epidemiologic Evidence

Exposure to varying forms of stress is an integral life experience that can provoke a variety of reactions. In research on alcohol, drug, and psychiatric disorders, the term “stress” often is understood to indicate any experience denoting adversity (Dohrenwend 2000). Stress exposures consist of external stimuli that are threatening or harmful; elicit fear, anxiety, anger, excitement, and/or...