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Alcohol Use Disorder and Traumatic Brain Injury

Alcohol use and traumatic brain injury (TBI) are inextricably and bidirectionally linked. Alcohol intoxication is one of the strongest predictors of TBI, and a substantial proportion of TBIs occur in intoxicated individuals. An inverse relationship is also emerging, such that TBI can serve as a risk factor for, or modulate the course of, alcohol use disorder (AUD). Critically, alcohol use after...

Alcohol and Puberty: Mechanisms of Delayed Development

Adolescence represents a vulnerable period for developing youth. Alcohol use and misuse are especially problematic behaviors during this time. Adolescents are more sensitive to alcohol and less tolerant of its detrimental effects than are adults. Research in humans and animals has revealed that early alcohol consumption can result in delayed pubertal development. Animal studies have shown that...

Alcohol’s Effects on the Brain: Neuroimaging Results in Humans and Animal Models

Brain imaging technology has allowed researchers to conduct rigorous studies of the dynamic course of alcoholism through periods of drinking, sobriety, and relapse and to gain insights into the effects of chronic alcoholism on the human brain. Magnetic resonance imaging (MRI) studies have distinguished alcohol-related brain effects that are permanent from those that are reversible with abstinence...

Pathophysiology of the Effects of Alcohol Abuse on the Endocrine System

Alcohol can permeate virtually every organ and tissue in the body, resulting in tissue injury and organ dysfunction. Considerable evidence indicates that alcohol abuse results in clinical abnormalities of one of the body’s most important systems, the endocrine system. This system ensures proper communication between various organs, also interfacing with the immune and nervous systems, and is...

Drinking Over the Lifespan: Focus on Early Adolescents and Youth

In describing patterns of alcohol use among early adolescents (ages 12–14) and youth (ages 15–20), there is both good news and bad news. The good news is that research findings with U.S. national epidemiology data from long-term annual surveys of high-school students, such as the Monitoring the Future surveys, have indicated historical shifts toward overall decreases in levels of alcohol use...

Social and Cultural Contexts of Alcohol Use: Influences in a Social–Ecological Framework

The alcohol research literature is overwhelmingly focused on risk factors, from the societal level down to the individual. Worldwide, 3.3 million deaths were attributed to alcohol misuse in 2012 (World Health Organization 2014). Excessive alcohol use is the third leading cause of death in the United States, accounting for 88,000 deaths per year (Centers for Disease Control and Prevention 2014)...

Under-Researched Demographics: Heavy Episodic Drinking and Alcohol-Related Problems Among Asian Americans

Recent Developments in Alcohol Services Research on Access to Care

Of the more than 18 million Americans who need treatment for alcohol use disorder (AUD), less than 10 percent actually receive care (Substance Abuse and Mental Health Services Administration [SAMHSA] 2013). This problem, often referred to as the substance abuse treatment gap, is a longstanding concern for alcohol services research. Studies suggest that many factors contribute to the treatment gap...

Alcohol Consumption in Demographic Subpopulations: An Epidemiologic Overview

Alcohol consumption is common across diverse populations in the United States; however, the level of consumption and its consequences vary considerably across major demographic subgroups. This review presents findings on the distribution and determinants of alcohol use and its aspects (i.e., age of onset, abstention vs. any drinking, binge drinking, and heavy drinking), alcohol abuse and dependen...

Associations Between Socioeconomic Factors and Alcohol Outcomes

According to the World Health Organization (2014), alcohol consumption is responsible for approximately 5.9 percent of deaths worldwide and a global loss of 139 million disability-adjusted life-years. The alcohol-related disease burden is precipitated in part by acute intoxication, which decreases reaction time, perception and motor skills, and inhibitions and is thereby associated with an...

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