Many service members and veterans seeking treatment for alcohol problems have experienced the life-threatening stress of combat, many have post-traumatic stress disorder (PTSD), and many service members and veterans seeking treatment for PTSD have alcohol or other substance problems. Sensitivity to these issues can influence how a therapist relates to the patient and also has possible implications...
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Drinking Over the Lifespan: Focus on College Ages
Approximately 41 percent of 18- to 24-year-olds are enrolled in a postsecondary degree-granting institution (National Center for Education Statistics 2013). As a group, college students, and particularly those at residential colleges (Presley et al. 2002), often drink heavily and experience myriad associated negative consequences. This selective review discusses the special characteristics of the...
The prevalence of alcohol use and the contrast between the drinking patterns of men and women vary widely across the globe. For instance, rates of current drinking ranged from 3 percent and 37 percent for women and men, respectively, in the Indian state of Karnataka to 94 percent and 97 percent for women and men in Denmark (Wilsnack et al. 2009). Overall, however, men have higher rates of alcohol...
Advances in Electrophysiological Research
The discovery and recording of electrical activity (electroencephalography [EEG]) in the human brain in 1924 by the German physician Hans Berger (Collura 1993; Haas 2003) has led to numerous scientific breakthroughs and clinical applications (Borck 2005; Gloor 1994). Recording brain activity in humans using scalp electrodes provides a noninvasive, sensitive measure of ongoing brain function during...
Long-lasting changes in synaptic function (i.e., synaptic plasticity) have long been thought to contribute to information storage in the nervous system (Kandel et al. 2014; Lovinger 2010). Studies combining behavioral and physiological analyses offer strong evidence supporting this hypothesis (Kandel et al. 2014; Ramirez et al. 2014). On the one hand, this plasticity allows the organism to adapt...
Alcohol Use As a Risk Factor in Infections and Healing: A Clinician's Perspective
Alcohol use and misuse have been part of human society for centuries. Early physicians recognized since the 1800s that alcohol produced not only impairment of the senses but also higher predisposition for tuberculosis. William Osler, the father of scientific medicine, reported in 1905 that patients who misused alcohol had higher predisposition to pneumonia (Osler 2001).
Between 2006 and 2010 in the...
Alcohol’s Burden on Immunity Following Burn, Hemorrhagic Shock, or Traumatic Brain Injury
The incidence of traumatic injury in alcohol-intoxicated individuals continues to escalate. According to the Centers for Disease Control and Prevention (2012a), more than 38 million American alcohol users consume 5 or more drinks on the same occasion (i.e., binge drink) and do so about 4 times per month. This behavior is highly conducive to unintentional or accidental traumatic injury, which...
A person with alcoholism engages in risky or dangerous drinking despite experiencing serious negative physical and social consequences. Such persistence in pursuing damaging behaviors suggests that the short-term “appetitive” results of drinking (such as intoxication and losing one’s inhibitions) have greater control over the alcoholic’s behavior than do the negative consequences. From a...
Neuroimmune Function and the Consequences of Alcohol Exposure
Effects of Alcohol on Tumor Growth, Metastasis, Immune Response, and Host Survival
Alcohol use and abuse have been implicated as etiological factors in the genesis of an increasing number of cancer types in both men and women. In 2012, the International Agency for Research on Cancer (IARC) listed both beverage alcohol (i.e., ethanol) and its major metabolite, acetaldehyde, as tumor-inducing substances (i.e., carcinogens) in humans. The most recent worldwide statistic from 2002...