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Computerized Cognitive–Behavioral Therapy

With an estimated 90 percent or more of alcohol use disorders going untreated (Substance Abuse and Mental Health Services Administration 2012), the search for interventions that easily, effectively, and economically reach more people has become a priority. The landmark 1990 report, Broadening the Base of Treatment for Alcohol Problems (Institute of Medicine 1990), refocused alcohol treatment...

NIH’s Adolescent Brain Cognitive Development Study (ABCD Study)

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ABCD Study logo

Adolescence is the stage of life during which most people begin using alcohol, and it is also a time of considerable social, psychological, and physiological change. The brain, particularly the frontal cortex, continues to develop throughout adolescence and does not fully mature until early adulthood. Adolescent alcohol exposure can impair brain development, compromise short- and long-term...

Cognitive Neuroscience Approaches to Understanding Behavior Change in Alcohol Use Disorder Treatments

Understanding the mechanisms that underlie recovery from alcohol use disorder (AUD) is critical to advancing AUD treatment science (Huebner and Tonigan 2007; National Institute on Alcohol Abuse and Alcoholism [NIAAA] 2009). Scientific progress over the last three decades has led to the development of a number of effective behavioral and pharmacological AUD interventions (Dutra et al. 2008)...

Alcohol's Unique Effects on Cognition in Women: A 2020 (Re)view to Envision Future Research and Treatment

Alcohol use and misuse is increasing among women. Although the prevalence of drinking remains higher in men than women, the gender gap is narrowing. This narrative review focuses on the cognitive sequelae of alcohol consumption in women. Studies of acute alcohol effects on cognition indicate that women typically perform worse than men on tasks requiring divided attention, memory, and decision...

Cognitive-Affective Transdiagnostic Factors Associated With Vulnerability to Alcohol and Prescription Opioid Use in the Context of Pain

Introduction

Pain is a complex, near-universal phenomenon, which can be conceptualized as a motivational state that engenders goal-directed action.1 Motivational models of substance use highlight the role of expected effects and suggest that individuals become motivated to use substances when such use is perceived as holding greater value than other available objects or events.2,3 A rapidly...

Behavioral Treatments for Alcohol Use Disorder and Post-Traumatic Stress Disorder

Alcohol use disorder (AUD) and post-traumatic stress disorder (PTSD) are highly prevalent and debilitating psychiatric conditions that commonly co-occur. Individuals with comorbid AUD and PTSD incur heightened risk for other psychiatric problems (e.g., depression and anxiety), impaired vocational and social functioning, and poor treatment outcomes. This review describes evidence-supported...

Brain Structure and Function in Recovery

Alcohol use disorder (AUD) commonly is associated with compromise in neurobiological and/or neurobehavioral processes. The severity of this compromise varies across individuals and outcomes, as does the degree to which recovery of function is achieved. This narrative review first summarizes neurobehavioral, neurophysiological, structural, and neurochemical aberrations/deficits that are frequently...

Alcohol Use Disorder and Traumatic Brain Injury

Alcohol use and traumatic brain injury (TBI) are inextricably and bidirectionally linked. Alcohol intoxication is one of the strongest predictors of TBI, and a substantial proportion of TBIs occur in intoxicated individuals. An inverse relationship is also emerging, such that TBI can serve as a risk factor for, or modulate the course of, alcohol use disorder (AUD). Critically, alcohol use after...

Advances in Electrophysiological Research

The discovery and recording of electrical activity (electroencephalography [EEG]) in the human brain in 1924 by the German physician Hans Berger (Collura 1993; Haas 2003) has led to numerous scientific breakthroughs and clinical applications (Borck 2005; Gloor 1994). Recording brain activity in humans using scalp electrodes provides a noninvasive, sensitive measure of ongoing brain function...

Binge Drinking’s Effects on the Developing Brain—Animal Models

Adolescence typically is a time of experimentation and emulation of adult behaviors, and many adolescents initiate alcohol and other drug (AOD) use during this developmental period. Brain development continues during adolescence, which could render the adolescent brain particularly vulnerable to alcohol’s effects. Consequently, adolescent alcohol exposure could result in long-lasting changes in...