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Stress and Alcohol: Epidemiologic Evidence
Exposure to varying forms of stress is an integral life experience that can provoke a variety of reactions. In research on alcohol, drug, and psychiatric disorders, the term “stress” often is understood to indicate any experience denoting adversity (Dohrenwend 2000). Stress exposures consist of external stimuli that are threatening or harmful; elicit fear, anxiety, anger, excitement, and/or...
Clinical Laboratory Stressors Used to Study Alcohol–Stress Relationships
A comprehensive understanding of the relationship between stress and alcohol use is important for understanding the risks of developing alcohol problems and subsequent relapse. Although the relationship is complex, substantial evidence supports that exposure to chronic stress early in life (e.g., Sher et al. 1997), adult trauma (Kessler et al. 1995), and the presence of anxiety disorders (Grant et...
Research is continuing to investigate how alcohol impacts chronic disease. The National Institute on Alcohol Abuse and Alcoholism (NIAAA) hosted a 2-day Expert Panel on Alcohol and Chronic Disease Epidemiology in August 2011 to review the state of the field on alcohol and chronic disease. The panel was chaired by Kenneth J. Mukamal, M.D., and Rosalind A. Breslow, Ph.D., M.P.H., R.D., and was...
Drinking Over the Lifespan: Focus on College Ages
Approximately 41 percent of 18- to 24-year-olds are enrolled in a postsecondary degree-granting institution (National Center for Education Statistics 2013). As a group, college students, and particularly those at residential colleges (Presley et al. 2002), often drink heavily and experience myriad associated negative consequences. This selective review discusses the special characteristics of the...
Macrophages and Alcohol-Related Liver Inflammation
Alcoholic liver disease (ALD) is a complex disease that affects millions of people worldwide and eventually can lead to liver cirrhosis and liver cancer (i.e., hepatocellular carcinoma). Aside from the direct cytotoxic and the oxidative-stress–mediated effects that alcohol and its metabolite, acetaldehyde, exert on hepatocytes, alcohol ingestion activates both the innate and adaptive immune...
For the past 25 years, a growing number of U.S. states have been progressively legalizing cannabis markets, first through the early adoption of medical cannabis laws, which enabled the purchase and possession of cannabis for specific medicinal purposes, and then more recently through laws regarding adult (i.e., “recreational”) use of cannabis. As of May 2021, more than 70% of U.S...
Community Indicators: Assessing the Impact of Alcohol Use on Communities
In the United States and other countries around the world, researchers have long been interested in community-level measurement of population health in the form of community indicators. Community indicators are measures that communicate information about a given dimension of a community’s well-being (Besleme and Mullin 1997). In the United States, the current popularity of community indicators can...
