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Nonconceptus Mechanisms of Prenatal Alcohol Exposure That Disrupt Embryo-Fetal Development: An Integrative View

Key Takeaways

  • Alcohol targets not just the embryo and fetus (i.e., the conceptus) but also the mother, biological father, placenta, and maternal microbiome to further disrupt embryo–fetal development.
  • Alcohol reprograms the maternal enteric microbiota and causes persistent alterations in the offspring’s microbiota, with potentially adverse consequences for the offspring’s immune system, gut mucosa...

Noncoding RNA and Alcohol Use Disorder: A Scoping Review of Current Research and Knowledge Gaps

Key Takeaways

  • Noncoding RNAs (ncRNAs) dominate the genomes of mammals, including humans, and epigenetically transduce the effects of the environment into all cells and tissues.
  • Understanding of the role of ncRNAs in the pathogenesis of alcohol use disorder (AUD) is in its infancy.
  • Most of the research has focused on very few classes of ncRNAs, mainly on microRNAs.
  • Research has mainly focused on...