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Recovery and Youth: An Integrative Review

Although rates of alcohol and other substance use disorders in adolescents have been estimated for decades, little is known about the prevalence, pathways, and predictors of remission and long-term recovery among adolescents. This article provides an integrative review of the literature on youth recovery. A final selection of 39 relevant articles was grouped into five sections: treatment outcomes...

The Role of the Family in Alcohol Use Disorder Recovery for Adults

Introduction

It is almost axiomatic that alcohol use disorder (AUD) and the family are inextricably bound. AUD harms individual family members and the functioning of the family as a whole, and family members’ actions may exacerbate problematic drinking. Conversely, families play a key role in recovery from AUD, and recovery has a positive impact on family members and family functioning...

Genetic and Environmental Determinants of Stress Responding

The development of alcohol dependence is a complex process influenced by both genetic and environmental risk factors (Prescott and Kendler 1999). The relative contributions of genetic and environmental influences fluctuate across development. During adolescence the initiation of alcohol use is strongly influenced by environmental factors (Dick et al. 2007; Heath et al. 1997; Karvonen 1995...

Alcohol Use As a Risk Factor in Infections and Healing: A Clinician's Perspective

Alcohol use and misuse have been part of human society for centuries. Early physicians recognized since the 1800s that alcohol produced not only impairment of the senses but also higher predisposition for tuberculosis. William Osler, the father of scientific medicine, reported in 1905 that patients who misused alcohol had higher predisposition to pneumonia (Osler 2001).

Between 2006 and 2010 in...

Pathophysiology of the Effects of Alcohol Abuse on the Endocrine System

Alcohol can permeate virtually every organ and tissue in the body, resulting in tissue injury and organ dysfunction. Considerable evidence indicates that alcohol abuse results in clinical abnormalities of one of the body’s most important systems, the endocrine system. This system ensures proper communication between various organs, also interfacing with the immune and nervous systems, and is...

Neuroimmune Function and the Consequences of Alcohol Exposure

Induction of neuroimmune genes by binge drinking increases neuronal excitability and oxidative stress, contributing to the neurobiology of alcohol dependence and causing neurodegeneration. Ethanol exposure activates signaling pathways featuring high-mobility group box 1 and Toll-like receptor 4 (TLR4), resulting in induction of the transcription factor nuclear factor kappa-light-chain-enhancer of...

Alcohol's Effect on Host Defense

Alcohol has been the most common substance of use and abuse in human history. Moderate amounts of alcohol are enjoyed for its anxiolytic effects; however, its addictive properties can lead to chronic, excessive alcohol use and alcohol use disorder. In addition to its commonly recognized behavioral effects, alcohol affects many organs, including the immune system that controls the body’s defense...

The Synaptic Interactions of Alcohol and the Endogenous Cannabinoid System

Introduction

Alcohol use disorder (AUD) is a chronic, relapsing brain disorder, characterized by a compromised ability to control alcohol use despite adverse occupational, social, or health consequences. Results from a 2019 National Survey on Drug Use and Health found that 5% of individuals over age 12 had AUD, affecting 14.5 million people in the United States. Alcohol and cannabis products are...

Advances in Electrophysiological Research

The discovery and recording of electrical activity (electroencephalography [EEG]) in the human brain in 1924 by the German physician Hans Berger (Collura 1993; Haas 2003) has led to numerous scientific breakthroughs and clinical applications (Borck 2005; Gloor 1994). Recording brain activity in humans using scalp electrodes provides a noninvasive, sensitive measure of ongoing brain function...

Alcohol’s Effects on the Brain: Neuroimaging Results in Humans and Animal Models

Brain imaging technology has allowed researchers to conduct rigorous studies of the dynamic course of alcoholism through periods of drinking, sobriety, and relapse and to gain insights into the effects of chronic alcoholism on the human brain. Magnetic resonance imaging (MRI) studies have distinguished alcohol-related brain effects that are permanent from those that are reversible with abstinence...