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Nonconceptus Mechanisms of Prenatal Alcohol Exposure That Disrupt Embryo-Fetal Development: An Integrative View

Key Takeaways

  • Alcohol targets not just the embryo and fetus (i.e., the conceptus) but also the mother, biological father, placenta, and maternal microbiome to further disrupt embryo–fetal development.
  • Alcohol reprograms the maternal enteric microbiota and causes persistent alterations in the offspring’s microbiota, with potentially adverse consequences for the offspring’s immune system, gut mucosa...