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Noncoding RNA and Alcohol Use Disorder: A Scoping Review of Current Research and Knowledge Gaps

Key Takeaways

  • Noncoding RNAs (ncRNAs) dominate the genomes of mammals, including humans, and epigenetically transduce the effects of the environment into all cells and tissues.
  • Understanding of the role of ncRNAs in the pathogenesis of alcohol use disorder (AUD) is in its infancy.
  • Most of the research has focused on very few classes of ncRNAs, mainly on microRNAs.
  • Research has mainly focused on...

Beyond the Brain: The Physical Health and Whole-Body Impact of Fetal Alcohol Spectrum Disorders

Key Takeaways

  • Recent clinical evidence integrated with the lived experiences of adolescents and adults with fetal alcohol spectrum disorder (FASD) highlights the range of physical health challenges people can experience.
  • Recent research suggests that comorbid physical health conditions may be associated with PAE across the life span for individuals with FASD. These conditions include metabolic...

The Relationship Between Alcohol-Related Content on Social Media and Alcohol Outcomes in Young Adults: A Scoping Review

Key Takeaways

  • The results of this scoping review confirm strong positive links between posting alcohol-related content (ARC) and drinking and alcohol-related problems.
  • The findings in this review underscore the need for operationalization and standardized measures related to ARC.
  • The authors propose a theoretical model—the Dual-Feedback Loop Drinking and ARC Model—that may serve as a blueprint for...

Influence of Alcohol on the Intestinal Immune System

Key Takeaways

  • Chronic alcohol consumption disrupts the intestinal barrier, causing dysbiosis, increased mucus thickness, and reduced antimicrobial peptides. This promotes bacterial translocation and systemic inflammation, which contribute to alcohol-associated liver disease (ALD).
  • Alcohol alters the intestinal immune system by disrupting the balance between immune tolerance and activation. This...

ARCR Editorial Staff

NIAAA/NIH Staff

Pamela Wernett, Ph.D., P.M.P.
Editor in Chief and Contracting Officer’s Representative

Pamela joined ARCR in 2018 as an Associate Editor and advanced to Editor in Chief for the journal in 2021. She has managed the journal contract with IQ Solutions as the Contracting Officer’s Representative since 2020. Pamela also serves as a Senior Health Science Policy Analyst within NIAAA’s...

FOIA

The Freedom of Information Act (FOIA), 5 U.S.C. 552 provides individuals with a right to access information in the possession of the U.S. federal government. The government, however, may withhold information covered by nine exemptions and three exclusions contained in the Act.

NIAAA FOIA Coordinator

Trevor Peterson
Freedom of Information Coordinator
31 CENTER DR RM 6A11 MSC 2510
BETHESDA, MD...

ARCR Celebrates Its 50th Anniversary

2024 marks the 50th anniversary of Alcohol Research: Current Reviews (ARCR), an open-access, peer-reviewed journal published by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) at the National Institutes of Health.