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Brain Structure and Function in Recovery
Recent Developments in Alcohol Services Research on Access to Care
Of the more than 18 million Americans who need treatment for alcohol use disorder (AUD), less than 10 percent actually receive care (Substance Abuse and Mental Health Services Administration [SAMHSA] 2013). This problem, often referred to as the substance abuse treatment gap, is a longstanding concern for alcohol services research. Studies suggest that many factors contribute to the treatment gap...
Uniting Epidemiology and Experimental Disease Models for Alcohol-Related Pancreatic Disease
Introduction
Pain is a complex, near-universal phenomenon, which can be conceptualized as a motivational state that engenders goal-directed action.1 Motivational models of substance use highlight the role of expected effects and suggest that individuals become motivated to use substances when such use is perceived as holding greater value than other available objects or events.2,3 A rapidly...
Fetal Alcohol Spectrum Disorders: Awareness to Insight in Just 50 Years
Introduction
The establishment of the National Institute on Alcohol Abuse and Alcoholism (NIAAA) in 1971 was bracketed by three seminal papers that laid the groundwork for the field of fetal alcohol spectrum disorders (FASD) research. In 1968, Lemoine et al.1 described children with birth defects and neurodevelopmental disorders associated with prenatal alcohol exposure (PAE). This French...
Pathophysiology of the Effects of Alcohol Abuse on the Endocrine System
Stress and the HPA Axis: Role of Glucocorticoids in Alcohol Dependence
Stress, generally defined as any stimulus that disrupts the body’s internal balance (i.e., physiological homeostasis), has long been suggested to be an important correlate of uncontrolled alcohol consumption or relapse to drinking following a period of abstinence. Large epidemiological studies have reported that a variety of stressors are associated with increased alcohol consumption and binge...
Impact of Continuing Care on Recovery From Substance Use Disorder
Alcohol and Skeletal Muscle in Health and Disease
Introduction
Alcohol misuse is the most common form of substance misuse and is associated with liver, cardiovascular, and metabolic diseases as well as with infections and cancers.1 Although an estimated 20% to 25% of people who drink heavily develop alcohol-related liver disease,2 40% to 60% of people with alcohol misuse have alcohol-related myopathy.3 Evidence that alcohol use leads to skeletal...