Post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) are common comorbid conditions that affect large segments of the population. Individuals with comorbid PTSD/AUD face greater clinical and functional stressors than those with diagnoses of either PTSD or AUD alone. The purpose of this article is to review the phenomenology and functional associations of PTSD/AUD and address the...
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Binge drinking thresholds have long been set at four or more drinks for women and five or more drinks for men over the course of a few hours. However, a significant number of people regularly consume much higher amounts of alcohol: double or even triple the standard binge drinking threshold. Researchers have begun to distinguish between typical binge drinking and this kind of “high-intensity...
“Maturing Out” of Binge and Problem Drinking
This article reviews literature aiming to explain the widespread reductions in binge and problem drinking that begin around the transition to young adulthood (i.e., “maturing out”). Whereas most existing literature on maturing out emphasizes contextual effects of transitions into adult roles and responsibilities, this article also reviews recent work demonstrating further effects of young adult...
Binge Drinking’s Effects on the Developing Brain—Animal Models
Adolescence typically is a time of experimentation and emulation of adult behaviors, and many adolescents initiate alcohol and other drug (AOD) use during this developmental period. Brain development continues during adolescence, which could render the adolescent brain particularly vulnerable to alcohol’s effects. Consequently, adolescent alcohol exposure could result in long-lasting changes in...
“Maturing Out” of Binge and Problem Drinking
This article reviews literature aiming to explain the widespread reductions in binge and problem drinking that begin around the transition to young adulthood (i.e., “maturing out”). Whereas most existing literature on maturing out emphasizes contextual effects of transitions into adult roles and responsibilities, this article also reviews recent work demonstrating further effects of young adult...
Co-occurring post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) are costly and consequential public health problems that negatively affect the health and well-being of U.S. military service members and veterans. The disproportionate burden of comorbid PTSD and AUD among U.S. military service members and veterans may be due to unique factors associated with military service, such...
Gender Differences in Binge Drinking
A large research literature shows that women consistently consume less alcohol than men, and they experience fewer social problems resulting from drinking than men, but these gender differences vary culturally, demographically, and historically.
Among the many organ systems affected by harmful alcohol use, the lungs are particularly susceptible to infections and injury. The mechanisms responsible for rendering people with alcohol use disorder (AUD) vulnerable to lung damage include alterations in host defenses of the upper and lower airways, disruption of alveolar epithelial barrier integrity, and alveolar macrophage immune dysfunction...
Pathophysiology of the Effects of Alcohol Abuse on the Endocrine System
Alcohol can permeate virtually every organ and tissue in the body, resulting in tissue injury and organ dysfunction. Considerable evidence indicates that alcohol abuse results in clinical abnormalities of one of the body’s most important systems, the endocrine system. This system ensures proper communication between various organs, also interfacing with the immune and nervous systems, and is...
Social and Cultural Contexts of Alcohol Use: Influences in a Social–Ecological Framework
The alcohol research literature is overwhelmingly focused on risk factors, from the societal level down to the individual. Worldwide, 3.3 million deaths were attributed to alcohol misuse in 2012 (World Health Organization 2014). Excessive alcohol use is the third leading cause of death in the United States, accounting for 88,000 deaths per year (Centers for Disease Control and Prevention 2014)...