During the first decade of the new millennium, remarkable advances in technology allowed investigators in all areas of biological research to collect massive amounts of genetic data at an unprecedented rate. The genomics revolution, which began with the sequencing of the human genome, was the basis for efforts such as the 1,000 Genomes Project (http://www.1000genomes.org/) that strive to compile a...
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Effects of Alcohol Dependence and Withdrawal on Stress Responsiveness and Alcohol Consumption
Although stress is known to be an important contributing factor to alcohol abuse and alcoholism, the interaction between stress and alcohol drinking behavior, as well as the mechanisms underlying this interaction in the context of dependence are complex and not well understood. On the one hand, alcohol is an effective anxiety-reducing agent (i.e., anxiolytic). Hence, motivation for drinking may be...
Alcohol and Cannabis Use and the Developing Brain
Introduction
Adolescence is marked by significant social, emotional, cognitive, and physical changes, as individuals transition from childhood to adulthood. Although the exact definition of adolescence tends to vary, recent findings regarding adolescent development and growth include individuals between the ages of 10 and 24.1 Consistent with this defined age range, the human brain continues to...
Alcohol’s Effects on the Brain: Neuroimaging Results in Humans and Animal Models
Bridging Animal and Human Models: Translating From (and to) Animal Genetics
Alcoholism is a complex disorder arising from a combination of genetic and environmental factors. The Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM–IV) (American Psychiatric Association 1994) requires that three of seven criteria be present during a 12-month period for a diagnosis of alcohol dependence. These criteria are tolerance, withdrawal symptoms, loss of control...
Alcohol Consumption in Demographic Subpopulations: An Epidemiologic Overview
Alcohol consumption is common across diverse populations in the United States; however, the level of consumption and its consequences vary considerably across major demographic subgroups. This review presents findings on the distribution and determinants of alcohol use and its aspects (i.e., age of onset, abstention vs. any drinking, binge drinking, and heavy drinking), alcohol abuse and dependen...
Community Indicators: Assessing the Impact of Alcohol Use on Communities
In the United States and other countries around the world, researchers have long been interested in community-level measurement of population health in the form of community indicators. Community indicators are measures that communicate information about a given dimension of a community’s well-being (Besleme and Mullin 1997). In the United States, the current popularity of community indicators can...
Effects of Alcohol on Tumor Growth, Metastasis, Immune Response, and Host Survival
Alcohol use and abuse have been implicated as etiological factors in the genesis of an increasing number of cancer types in both men and women. In 2012, the International Agency for Research on Cancer (IARC) listed both beverage alcohol (i.e., ethanol) and its major metabolite, acetaldehyde, as tumor-inducing substances (i.e., carcinogens) in humans. The most recent worldwide statistic from 2002...
Alcoholic Myopathy: Pathophysiologic Mechanisms and Clinical Implications
Associations Between Socioeconomic Factors and Alcohol Outcomes
According to the World Health Organization (2014), alcohol consumption is responsible for approximately 5.9 percent of deaths worldwide and a global loss of 139 million disability-adjusted life-years. The alcohol-related disease burden is precipitated in part by acute intoxication, which decreases reaction time, perception and motor skills, and inhibitions and is thereby associated with an...