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Advances in Electrophysiological Research

The discovery and recording of electrical activity (electroencephalography [EEG]) in the human brain in 1924 by the German physician Hans Berger (Collura 1993; Haas 2003) has led to numerous scientific breakthroughs and clinical applications (Borck 2005; Gloor 1994). Recording brain activity in humans using scalp electrodes provides a noninvasive, sensitive measure of ongoing brain function...

Measuring the Burden - Editor's Note

Alcohol use is associated with tremendous costs to the drinker, those around him or her, and society as a whole. These costs result from the increased health risks (both physical and mental) associated with alcohol consumption as well as from the social harms caused by alcohol. This issue of Alcohol Research: Current Reviews examines the public health impact of alcohol consumption, looking at the...

Advances in Human Neuroconnectivity Research: Applications for Understanding Familial History Risk for Alcoholism

Advances in human neuroimaging have expanded our ability to understand the functioning of the brain, with particular recent advances fostering our analytic capacity to examine networks between the brain’s nerve cells (i.e., neurons) and neuroconnectivity (i.e., neural networks). Relevant to the field of alcoholism, several researchers recently have applied these strategies to groups at genetic...

Alcohol Research and eHealth Technology - Editor's Note

The rapid advance of electronic technology holds the promise for revolutionary improvements in conducting research on alcohol use disorders as well as innovative methods for prevention and treatment. This issue of Alcohol Research: Current Reviews reports on the state of the science and future directions in electronic health (eHealth) technologies and their potential impact on alcohol epidemiology...

Drinking Patterns and Their Definitions

The number of drinks a person consumes and the rate at which he or she consumes them influence how much alcohol enters the brain and how impaired that person becomes. Many people are surprised to learn what counts as a drink. The amount of liquid in one’s glass, can, or bottle does not necessarily match up to how much alcohol is in the drink. To facilitate research and clinical care and to help...

Low to Moderate Prenatal Alcohol Exposure and Neurodevelopmental Outcomes: A Narrative Review and Methodological Considerations

Introduction

Prenatal alcohol exposure (PAE) is a necessary cause of fetal alcohol spectrum disorders (FASD), a group of alcohol-related conditions characterized by neurodevelopmental problems. Although PAE is associated with many adverse physical, neurodevelopmental, and social outcomes, the most commonly studied are neurodevelopmental—primarily behavioral and cognitive—outcomes. Associations...

“Maturing Out” of Binge and Problem Drinking

This article reviews literature aiming to explain the widespread reductions in binge and problem drinking that begin around the transition to young adulthood (i.e., “maturing out”). Whereas most existing literature on maturing out emphasizes contextual effects of transitions into adult roles and responsibilities, this article also reviews recent work demonstrating further effects of young adult...

Alcohol and Puberty: Mechanisms of Delayed Development

Adolescence represents a vulnerable period for developing youth. Alcohol use and misuse are especially problematic behaviors during this time. Adolescents are more sensitive to alcohol and less tolerant of its detrimental effects than are adults. Research in humans and animals has revealed that early alcohol consumption can result in delayed pubertal development. Animal studies have shown that...

Alcoholic Liver Disease: Pathogenesis and Current Management

Excessive alcohol consumption is a global healthcare problem. The liver sustains the greatest degree of tissue injury by heavy drinking because it is the primary site of ethanol metabolism. Chronic and excessive alcohol consumption produces a wide spectrum of hepatic lesions, the most characteristic of which are steatosis, hepatitis, and fibrosis/cirrhosis. Steatosis is the earliest response to...

Neuroplasticity and Predictors of Alcohol Recovery

Recovery from alcoholism is a complex and long-term process with high relapse rates. Therefore, understanding why people relapse has been critically important to improving treatment outcomes. To that end, researchers are looking for clinical and biological markers that predict relapse after treatment and to use those risk factors to develop effective treatments to reduce relapse rates. One...